Gangadharan, receiving no financial support ĭr. Ebright, receiving no financial support ĭr. ![]() Blackmon, reports receiving no financial support ĭr. Reddy, MD, University of Michigan Medical School Benny Weksler, MD, Allegheny General Hospitalįunding for this study was provided by On Target Laboratories, Inc.ĭr. Parekh, MBBS, University of Iowa Carver College of Medicine Rishindra M. Murthy, MD, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University Kalpaj R. Louie, MD, Swedish Cancer Institute and Medical Center Sudish C. Ebright, MD, Columbia University Medical Center Sidharta Peña Gangadharan, MD, Beth Israel Deaconess Medical Center Brian E. Further research is needed to examine naturally-acquired immunity against Omicron and newer emerging variants. Additionally, we found that ages 5-11 years exhibited no significant waning of naturally acquired protection throughout the outcome period, whereas waning protection in the 12-18 year-old age group was more prominent, but still mild.Ĭhildren and adolescents who were previously infected with SARS-CoV-2 remain protected to a high degree for 18 months. Effectiveness of naturally-acquired immunity against a recurrent infection reached 89.2% (95% CI: 84.7%-92.4%) three to six months after first infection, mildly declining to 82.5% (95% CI, 79.1%-85.3%) 9-12 months after infection, with a slight non-significant waning trend up to 18 months after infection. Importantly, no SARS-CoV-2-related deaths were recorded in either the SARS-CoV-2 naïve group or the previously infected group. Overall, children and adolescents who were previously infected acquired durable protection against reinfection with SARS-CoV-2 for at least 18 months. We evaluated three SARS-CoV-2-related outcomes: documented PCR confirmed infection or reinfection, symptomatic infection or reinfection, and SARS-CoV-2-related hospitalization or death. Analyses focused on July 1 to December 13, 2021, a period of Delta variant dominance in Israel. ![]() 458,959 unvaccinated individuals aged 5-18 years were included. We applied two complementary approaches: a matched test-negative, case-control design and a retrospective cohort design. To evaluate the duration of protection against reinfection conferred by a previous SARS-CoV-2 infection in children and adolescents. In the multivariate analysis, enlarged left atrium (LA) (adjusted odds ratio =1.03, 95% confidential interval, 1.007–1.061 p=0.013) and single confluent lesion pattern (aOR= 1.55, 95% CI, 1.012–2.381 p=0.044) were associated with right hemispheric lesions.Įnlarged LA and single confluent lesion pattern were strongly related to right-sided propensity in patients with AF-stroke. Right and left hemispheric lesions were observed in 189 (49.1 %) and 196 (50.9%) patients, respectively. Factors associated with right-side propensity were analyzed.Īmong 385 patients, the mean age was 74☑1 years and 52.5 % were male. Patients were grouped based on whether lesions were right or left hemispheric in the anterior circulation territory, based on diffusion-weighted imaging. We retrospectively reviewed patients with acute AF-stroke admitted from January, 2017 to March, 2022. In this study, we compared the hemispheric differences among patients with AF-stroke and identified factors associated with lesion laterality. Propensity for lesion lateralization in atrial fibrillation-related cardiac embolic stroke (AF-stroke) remains controversial.
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